The frequency of POLE-mutation in endometrial carcinoma and prognostic implications: a systemic review and meta-analysis

• Main Authors: Alaa Salah Jumaah (Author), Mais Muhammed Salim (Author), Hawraa Sahib Al-Haddad (Author), Katherine Ann McAllister (Author), Akeel Abed Yasseen (Author)
• Format: Book
• Published: Korean Society of Pathologists & the Korean Society for Cytopathology, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background Endometrial carcinoma (EC) is classified into four distinct molecular subgroups including ultramutated DNA polymerase epsilon (POLE). POLE-mutated tumors have the best prognosis and are a promising target for immunotherapy. This meta-analysis consolidated the reported variation of POLE-mu...