Rational repurposing, synthesis, in vitro and in silico studies of chromone-peptidyl hybrids as potential agents against Leishmania donovani

• প্রধান লেখক: Ahmed H. E. Hassan (লেখক), Waleed A. Bayoumi (লেখক), Selwan M. El-Sayed (লেখক), Trong-Nhat Phan (লেখক), Yeon Ju Kim (লেখক), Chae Hyeon Lee (লেখক), Soo Bin Cho (লেখক), Taegeun Oh (লেখক), Gyeongpyo Ham (লেখক), Kazem Mahmoud (লেখক), Joo Hwan No (লেখক), Yong Sup Lee (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

A chromone-peptidyl hybrids series was synthesised and rationally repurposed towards identification of potential antileishmanial hits against visceral leishmaniasis. Three hybrids 7c, 7n, and 7h showed potential IC50 values (9.8, 10, and 12 µM, respectively) which were comparable to erufosine IC50 (...