RGC-specific ATF4 and/or CHOP deletion rescues glaucomatous neurodegeneration and visual function

• Main Authors: Fang Fang (Author), Pingting Liu (Author), Haoliang Huang (Author), Xue Feng (Author), Liang Li (Author), Yang Sun (Author), Randal J. Kaufman (Author), Yang Hu (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endoplasmic reticulum (ER) stress has been linked with various acute and chronic neurodegenerative diseases. We previously found that optic nerve (ON) injury and diseases induce neuronal ER stress in retinal ganglion cells (RGCs). We further demonstrated that germline deletion of CHOP preserves the...