l-Type amino acid transporter 1-targeting nanoparticles for antisense oligonucleotide delivery to the CNS

• Main Authors: Yu Na Lim (Author), In Soo Ryu (Author), Yeon-Joo Jung (Author), Gabriel Helmlinger (Author), Insun Kim (Author), Hye Won Park (Author), Hansol Kang (Author), Jina Lee (Author), Hyo Jin Lee (Author), Kang Seon Lee (Author), Ha-Na Jang (Author), Dae-In Ha (Author), Junghyung Park (Author), Jinyoung Won (Author), Kyung Seob Lim (Author), Chang-Yeop Jeon (Author), Hyun-Jeong Cho (Author), Hyun Su Min (Author), Jin-Hyeob Ryu (Author)
• פורמט: ספר
• יצא לאור: Elsevier, 2024-12-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

l-Type amino acid transporter 1 (LAT1)-specific ligands and polyion complexes are used as brain-specific targets to deliver RNA-based drugs across the blood-brain barrier. We characterized an LAT1-targeting antisense oligonucleotide (ASO)-encapsulated nanoparticle, Phe-NPs/ASO. A 25% density of phen...