An Algorithm for Nonparametric Estimation of a Multivariate Mixing Distribution with Applications to Population Pharmacokinetics

• Main Authors: Walter M. Yamada (Author), Michael N. Neely (Author), Jay Bartroff (Author), David S. Bayard (Author), James V. Burke (Author), Mike van Guilder (Author), Roger W. Jelliffe (Author), Alona Kryshchenko (Author), Robert Leary (Author), Tatiana Tatarinova (Author), Alan Schumitzky (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Population pharmacokinetic (PK) modeling has become a cornerstone of drug development and optimal patient dosing. This approach offers great benefits for datasets with sparse sampling, such as in pediatric patients, and can describe between-patient variability. While most current algorithms assume n...