Chronopharmacology of Mizoribine in Collagen-Induced Arthritis Rats

• Main Authors: Yuko Kanasaki (Author), Mari Tomonari (Author), Hitoshi Sasaki (Author), Hideto To (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously reported that higher therapeutic effects were obtained in rheumatoid arthritis (RA) patients and RA model animals when the dosing-times of methotrexate and tacrolimus were chosen according to the 24-h rhythms of the inflammatory response. Mizoribine (MZR) is an immunosuppressive agent...