The Role of Non-Enzymatic Degradation of Meropenem-Insights from the Bottle to the Body

• Main Authors: Uwe Liebchen (Author), Sophie Rakete (Author), Michael Vogeser (Author), Florian M. Arend (Author), Christina Kinast (Author), Christina Scharf (Author), Michael Zoller (Author), Ulf Schönermarck (Author), Michael Paal (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Several studies have addressed the poor stability of meropenem in aqueous solutions, though not considering the main degradation product, the open-ring metabolite (ORM) form. In the present work, we elucidate the metabolic fate of meropenem and ORM from continuous infusion to the human bloodstream....