Factors Affecting the Metabolic Conversion of Ciprofloxacin and Exposure to Its Main Active Metabolites in Critically Ill Patients: Population Pharmacokinetic Analysis of Desethylene Ciprofloxacin

• المؤلفون الرئيسيون: Martin Šíma (مؤلف), Daniel Bobek (مؤلف), Petra Cihlářová (مؤلف), Pavel Ryšánek (مؤلف), Jaroslava Roušarová (مؤلف), Jan Beroušek (مؤلف), Martin Kuchař (مؤلف), Tomáš Vymazal (مؤلف), Ondřej Slanař (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2022-08-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The objective of this prospective study was to examine the exposure to the main active metabolites of ciprofloxacin in critically ill patients and to examine the factors (demographic, laboratory and genetic) that could potentially affect the drug metabolic conversion of ciprofloxacin. The secondary...