Safety and pharmacokinetics of docetaxel in combination with pegvorhyaluronidase alfa in patients with non‐small cell lung cancer

• Main Authors: Thomas Heineman (Author), Megan Baumgart (Author), Charvi Nanavati (Author), Nash Gabrail (Author), Scott A. Van Wart (Author), Donald E. Mager (Author), Daniel C. Maneval (Author), Anas M. Fathallah (Author), Rose E. Sekulovich (Author)
• Format: Book
• Published: Wiley, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract This open‐label, phase Ib study (NCT02346370) assessed the effect of pegvorhyaluronidase alfa (PVHA; PEGPH20) on the plasma pharmacokinetics (PKs) and safety of docetaxel in 15 patients with stage IIIB/IV non‐small cell lung cancer (NSCLC). The docetaxel PK profile from this study was consi...