Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model

• Main Authors: Michael Schütt (Author), Connor O'Farrell (Author), Konstantinos Stamatopoulos (Author), Caroline L. Hoad (Author), Luca Marciani (Author), Sarah Sulaiman (Author), Mark J. H. Simmons (Author), Hannah K. Batchelor (Author), Alessio Alexiadis (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic Colon Model; a physiologically representative in v...