Preclinical In Vivo Evaluation of the Safety of a Multi-shRNA-based Gene Therapy Against HIV-1

• Main Authors: Mireille Centlivre (Author), Nicolas Legrand (Author), Sofieke Klamer (Author), Ying Poi Liu (Author), Karin Jasmijn von Eije (Author), Martino Bohne (Author), Esther Siteur-van Rijnstra (Author), Kees Weijer (Author), Bianca Blom (Author), Carlijn Voermans (Author), Hergen Spits (Author), Ben Berkhout (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Highly active antiretroviral therapy (HAART) has significantly improved the quality of life and the life expectancy of HIV-infected individuals. Still, drug-induced side effects and emergence of drug-resistant viral variants remain important issues that justify the exploration of alternative therape...