Zoledronic acid induces ferroptosis by reducing ubiquinone and promoting HMOX1 expression in osteosarcoma cells

• Main Authors: Tianhao Ren (Author), Ju Huang (Author), Wei Sun (Author), Guangze Wang (Author), Yuwen Wu (Author), Zewei Jiang (Author), Yingshuai Lv (Author), Guang Wu (Author), Jiawei Cao (Author), Min Liu (Author), Haihua Gu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: Ferroptosis plays important roles in tumorigenesis and cancer therapy. Zoledronic acid is known to inhibit the activity of farnesyl pyrophosphate synthase, a key enzyme in the mevalonate pathway. We examined whether zoledronic acid can inhibit the growth of osteosarcoma cells by inducing ferro...