Adenovirus and Oxaliplatin cooperate as agnostic sensitizers for immunogenic cell death in colorectal carcinoma

• Main Authors: J. Milburn Jessup (Author), Mohamed Kabbout (Author), Nikolay Korokhov (Author), Alex Joun (Author), Ann E. Tollefson (Author), William S. M. Wold (Author), Abid R. Mattoo (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Treatments with cytotoxic agents or viruses may cause Immunogenic Cell Death (ICD) that immunize tumor-bearing hosts but do not cause complete regression of tumor. We postulate that combining two ICD inducers may cause durable regression in immunocompetent mice. ICD was optimized in vitro by maximiz...