Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion

• Main Authors: Jarrett R. Remsberg (Author), Benjamin N. Ediger (Author), Wesley Y. Ho (Author), Manashree Damle (Author), Zhenghui Li (Author), Christopher Teng (Author), Cristina Lanzillotta (Author), Doris A. Stoffers (Author), Mitchell A. Lazar (Author)
• Format: Book
• Published: Elsevier, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Histone deacetylases are epigenetic regulators known to control gene transcription in various tissues. A member of this family, histone deacetylase 3 (HDAC3), has been shown to regulate metabolic genes. Cell culture studies with HDAC-specific inhibitors and siRNA suggest that HDAC3 plays...