Mouse myofibers lacking the SMYD1 methyltransferase are susceptible to atrophy, internalization of nuclei and myofibrillar disarray

• Main Authors: M. David Stewart (Author), Suhujey Lopez (Author), Harika Nagandla (Author), Benjamin Soibam (Author), Ashley Benham (Author), Jasmine Nguyen (Author), Nicolas Valenzuela (Author), Harry J. Wu (Author), Alan R. Burns (Author), Tara L. Rasmussen (Author), Haley O. Tucker (Author), Robert J. Schwartz (Author)
• Format: Book
• Published: The Company of Biologists, 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Smyd1 gene encodes a lysine methyltransferase specifically expressed in striated muscle. Because Smyd1-null mouse embryos die from heart malformation prior to formation of skeletal muscle, we developed a Smyd1 conditional-knockout allele to determine the consequence of SMYD1 loss in mammalian sk...