A reporter gene assay for determining the biological activity of therapeutic antibodies targeting TIGIT

• Main Authors: Zhihao Fu (Author), Hongchuan Liu (Author), Lan Wang (Author), Chuanfei Yu (Author), Yalan Yang (Author), Meiqing Feng (Author), Junzhi Wang (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

T cell immunoglobulin and ITIM domain (TIGIT) is a novel immune checkpoint that has been considered as a target in cancer immunotherapy. Current available bioassays for measuring the biological activity of therapeutic antibodies targeting TIGIT are restricted to mechanistic investigations because do...