AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology

• Main Authors: Natasha Jaiswal (Author), Matthew Gavin (Author), Emanuele Loro (Author), Jaimarie Sostre‐Colón (Author), Paul A. Roberson (Author), Kahealani Uehara (Author), Nicole Rivera‐Fuentes (Author), Michael Neinast (Author), Zoltan Arany (Author), Scot R. Kimball (Author), Tejvir S. Khurana (Author), Paul M. Titchenell (Author)
• Format: Book
• Published: Wiley, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Skeletomuscular diseases result in significant muscle loss and decreased performance, paralleled by a loss in mitochondrial and oxidative capacity. Insulin and insulin‐like growth factor‐1 (IGF‐1) are two potent anabolic hormones that activate a host of signalling intermediates i...