Preclinical Evaluation of a New Format of ⁶⁸Ga- and ¹¹¹In-Labeled Affibody Molecule Z_IGF-1R:4551 for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT

• Main Authors: Yongsheng Liu (Author), Shengze Yu (Author), Tianqi Xu (Author), Vitalina Bodenko (Author), Anna Orlova (Author), Maryam Oroujeni (Author), Sara S. Rinne (Author), Vladimir Tolmachev (Author), Anzhelika Vorobyeva (Author), Torbjörn Gräslund (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Insulin-like growth factor-1 receptor (IGF-1R) is a molecular target for several monoclonal antibodies undergoing clinical evaluation as anticancer therapeutics. The non-invasive detection of IGF-1R expression in tumors might enable stratification of patients for specific treatment and improve t...