Molecular Landscape of ERBB2 Alterations in 14,956 Solid Tumors

• Main Authors: Hao Wang (Author), Ji Miao (Author), Yazhou Wen (Author), Xihua Xia (Author), Yanan Chen (Author), Mengli Huang (Author), Shiqing Chen (Author), Zhengyi Zhao (Author), Yuzi Zhang (Author), Chunzhu Chen (Author), Xinhua Zhu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ERBB2 abnormalities frequently occur and serve as rationale therapeutic targets in cancer. In this study, clinical and next-generation sequencing data from 14,956 patients across more than 20 tumor types were collected. A total of 406 (2.7%) patients were identified with ERBB2 amplifications, and 30...