Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish

• Main Authors: Yonghe Ding (Author), Alexey V. Dvornikov (Author), Xiao Ma (Author), Hong Zhang (Author), Yong Wang (Author), Matthew Lowerison (Author), Rene R. Packard (Author), Lei Wang (Author), Jun Chen (Author), Yuji Zhang (Author), Tzung Hsiai (Author), Xueying Lin (Author), Xiaolei Xu (Author)
• Format: Book
• Published: The Company of Biologists, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The adult zebrafish is an emerging vertebrate model for studying human cardiomyopathies; however, whether the simple zebrafish heart can model different subtypes of cardiomyopathies, such as dilated cardiomyopathy (DCM), remains elusive. Here, we generated and characterized an inherited DCM model in...