Pharmacological intervention in hepatic stellate cell activation and hepatic fibrosis

• Main Authors: Hans-Theo eSchon (Author), Matthias eBartneck (Author), Erawan eBorkham-Kamphorst (Author), Jacob eNattermann (Author), Twan eLammers (Author), Frank eTacke (Author), Ralf eWeiskirchen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The activation and transdifferentiation of hepatic stellate cells (HSCs) into contractile, matrix-producing myofibroblasts (MFBs) are central events in hepatic fibrogenesis. These processes are driven by autocrine- and paracrine-acting soluble factors (i.e. cytokines and chemokines). Proof-of-concep...