Exploratory window‐of‐opportunity trial to investigate the tumor pharmacokinetics/pharmacodynamics of the IAP antagonist Debio 1143 in patients with head and neck cancer

Exploratory window‐of‐opportunity trial to investigate the tumor pharmacokinetics/pharmacodynamics of the IAP antagonist Debio 1143 in patients with head and neck cancer

Abstract Inhibitor of apoptosis proteins (IAPs) regulate apoptosis and modulate NF‐κB signaling thereby driving expression of genes involved in immune/inflammatory responses. The orally available IAP antagonist Debio 1143 has potential to enhance tumor response to chemoradiotherapy and/or immunother...

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Main Authors: Carlos Gomez‐Roca (Author), Caroline Even (Author), Christophe Le Tourneau (Author), Neus Basté (Author), Jean‐Pierre Delord (Author), Jerome Sarini (Author), Sebastien Vergez (Author), Stephane Temam (Author), Caroline Hoffmann (Author), Philippe Rochaix (Author), Edith Borcoman (Author), Bruno Gavillet (Author), Elisabeth Rouits (Author), Annick Ménétrey (Author), Franck Brichory (Author), Daniela Purcea (Author), Gregoire Vuagniaux (Author), Claudio Zanna (Author)
Format: Book
Published: Wiley, 2022-01-01T00:00:00Z.
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