Multiscale molecular profiling of pathological bone resolves sexually dimorphic control of extracellular matrix composition

• Main Authors: Aikta Sharma (Author), Alice Goring (Author), Peter B. Johnson (Author), Roger J. H. Emery (Author), Eric Hesse (Author), Alan Boyde (Author), Bjorn R. Olsen (Author), Andrew A. Pitsillides (Author), Richard O. C. Oreffo (Author), Sumeet Mahajan (Author), Claire E. Clarkin (Author)
• Format: Book
• Published: The Company of Biologists, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Collagen assembly during development is essential for successful matrix mineralisation, which determines bone quality and mechanocompetence. However, the biochemical and structural perturbations that drive pathological skeletal collagen configuration remain unclear. Deletion of vascular endothelial...