A Selective Adenylyl Cyclase 1 Inhibitor Relieves Pain Without Causing Tolerance

• Main Authors: Gianna Giacoletti (Author), Tatum Price (Author), Lucas V. B. Hoelz (Author), Abdulwhab Shremo Msdi (Author), Samantha Cossin (Author), Katerina Vazquez-Falto (Author), Tácio V. Amorim Fernandes (Author), Vinícius Santos de Pontes (Author), Hongbing Wang (Author), Nubia Boechat (Author), Adwoa Nornoo (Author), Tarsis F. Brust (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Among the ten different adenylyl cyclase isoforms, studies with knockout animals indicate that inhibition of AC1 can relieve pain and reduce behaviors linked to opioid dependence. We previously identified ST034307 as a selective inhibitor of AC1. The development of an AC1-selective inhibitor now pro...