Computer-aided scoring of erb-b2 receptor tyrosine kinase 2 (HER2) gene amplification status in breast cancer

• Main Authors: Alyson Yoder (Author), Landon J. Inge (Author), Chen-Chun Chen (Author), Vijay R. Marati (Author), Trung Kien Nguyen (Author), Karel Zuiderveld (Author), Jim Martin (Author), Sarah Gladden (Author), Mohammad Saleh Miri (Author), Raghavan Venugopal (Author), Bryan Lopez (Author), Jim Ranger-Moore (Author), Christoph Guetter (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Identification of HER2 protein overexpression and/or amplification of the HER2 gene are required to qualify breast cancer patients for HER2 targeted therapies. In situ hybridization (ISH) assays that identify HER2 gene amplification function as a stand-alone test for determination of HER...