Metformin suppresses phenylephrine-induced hypertrophic responses by inhibiting p300-HAT activity in cardiomyocytes

• Main Authors: Yoichi Sunagawa (Author), Kiyotaka Shimizu (Author), Ayumi Katayama (Author), Masafumi Funamoto (Author), Kana Shimizu (Author), Sari Nurmila (Author), Satoshi Shimizu (Author), Yusuke Miyazaki (Author), Yasufumi Katanasaka (Author), Koji Hasegawa (Author), Tatsuya Morimoto (Author)
• Format: Book
• Published: Elsevier, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Heart failure is the final pathway for a wide spectrum of myocardial stress, including hypertension and myocardial infarction. However, the potential effects of metformin on cardiac hypertrophy are still unclear. Purpose: The purpose of this study was to investigate whether metformin l...