ACTN3 GENOTYPE IS ASSOCIATED WITH TESTOSTERONE LEVELS OF ATHLETES

• Main Authors: I.I. Ahmetov (Author), A.E. Donnikov (Author), D.Y. Trofimov (Author)
• Format: Book
• Published: Termedia Publishing House, 2014-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

α-Actinin-3 (ACTN3) has been proposed to regulate skeletal muscle differentiation and hypertrophy through its interaction with the signalling protein calcineurin. Since the inhibition of calcineurin potentiates the production of testosterone, we hypothesized that α-actinin-3 deficiency (predicted fr...