Regulation of biotransformation systems and ABC transporters by benznidazole in HepG2 cells: involvement of pregnane X-receptor.

• Main Authors: Juan P Rigalli (Author), Virginia G Perdomo (Author), Marcelo G Luquita (Author), Silvina S M Villanueva (Author), Agostina Arias (Author), Dirk Theile (Author), Johanna Weiss (Author), Aldo D Mottino (Author), María L Ruiz (Author), Viviana A Catania (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Benznidazole (BZL) is the only antichagasic drug available in most endemic countries. Its effect on the expression and activity of drug-metabolizing and transporter proteins has not been studied yet. METHODOLOGY/PRINCIPAL FINDINGS: Expression and activity of P-glycoprotein (P-gp), Multid...