Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis

• المؤلفون الرئيسيون: Veronica Di Paolo (مؤلف), Chiara Fulci (مؤلف), Dante Rotili (مؤلف), Francesca Sciarretta (مؤلف), Alessia Lucidi (مؤلف), Blasco Morozzo della Rocca (مؤلف), Anastasia De Luca (مؤلف), Antonio Rosato (مؤلف), Luigi Quintieri (مؤلف), Anna Maria Caccuri (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The antitumor agent 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (1) is a potent inhibitor of GSTP1-1, a glutathione S-transferase capable of inhibiting apoptosis by binding to JNK1 and TRAF2. We recently demonstrated that, unlike its parent compound, the benzoyl ester of 1 (compound 3)...