Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)

• Main Authors: Christian A. Maiwald (Author), Kim V. Annink (Author), Mario Rüdiger (Author), Manon J. N. L. Benders (Author), Frank van Bel (Author), Karel Allegaert (Author), Gunnar Naulaers (Author), Dirk Bassler (Author), Katrin Klebermaß-Schrehof (Author), Maximo Vento (Author), Hercilia Guimarães (Author), Tom Stiris (Author), Luigi Cattarossi (Author), Marjo Metsäranta (Author), Sampsa Vanhatalo (Author), Jan Mazela (Author), Tuuli Metsvaht (Author), Yannique Jacobs (Author), Axel R. Franz (Author), for the ALBINO Study Group (Author)
• Format: Book
• Published: BMC, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Perinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major cause of death and long-term disability in term born neonates. Up to 20,000 infants each year are affected by HIE in Europe and even more in regions with lower level of perinatal care. The only establishe...