ZINC40099027 activates human focal adhesion kinase by accelerating the enzymatic activity of the FAK kinase domain

ZINC40099027 activates human focal adhesion kinase by accelerating the enzymatic activity of the FAK kinase domain

Abstract Focal adhesion kinase (FAK) regulates gastrointestinal epithelial restitution and healing. ZINC40099027 (Zn27) activates cellular FAK and promotes intestinal epithelial wound closure in vitro and in mice. However, whether Zn27 activates FAK directly or indirectly remains unknown. We evaluat...

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Main Authors: Rashmi (Author), Shyam K. More (Author), Qinggang Wang (Author), Emilie E. Vomhof‐DeKrey (Author), James E. Porter (Author), Marc D. Basson (Author)
Format: Book
Published: Wiley, 2021-04-01T00:00:00Z.
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