Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent

• Main Authors: Jan Mersmann (Author), Franziska Iskandar (Author), Kathrina Latsch (Author), Katharina Habeck (Author), Vera Sprunck (Author), René Zimmermann (Author), Ralf R. Schumann (Author), Kai Zacharowski (Author), Alexander Koch (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genetic or pharmacological ablation of toll-like receptor 2 (TLR2) protects against myocardial ischemia/reperfusion injury (MI/R). However, the endogenous ligand responsible for TLR2 activation has not yet been detected. The objective of this study was to identify HMGB1 as an activator of TLR2 signa...