Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent

• Prif Awduron: Jan Mersmann (Awdur), Franziska Iskandar (Awdur), Kathrina Latsch (Awdur), Katharina Habeck (Awdur), Vera Sprunck (Awdur), René Zimmermann (Awdur), Ralf R. Schumann (Awdur), Kai Zacharowski (Awdur), Alexander Koch (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Hindawi Limited, 2013-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Genetic or pharmacological ablation of toll-like receptor 2 (TLR2) protects against myocardial ischemia/reperfusion injury (MI/R). However, the endogenous ligand responsible for TLR2 activation has not yet been detected. The objective of this study was to identify HMGB1 as an activator of TLR2 signa...