A guide to developing population files for physiologically‐based pharmacokinetic modeling in the Simcyp Simulator

• Hoofdauteurs: Liam Curry (Auteur), Sarah Alrubia (Auteur), Frederic Y. Bois (Auteur), Ruth Clayton (Auteur), Eman El‐Khateeb (Auteur), Trevor N. Johnson (Auteur), Muhammad Faisal (Auteur), Sibylle Neuhoff (Auteur), Kris Wragg (Auteur), Amin Rostami‐Hodjegan (Auteur)
• Formaat: Boek
• Gepubliceerd in: Wiley, 2024-09-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract The Simcyp Simulator is a software platform widely used in the pharmaceutical industry to conduct stochastic physiologically‐based pharmacokinetic (PBPK) modeling. This approach has the advantage of combining routinely generated in vitro data on drugs and drug products with knowledge of bio...