Astragalus Polysaccharide RAP Selectively Attenuates Paclitaxel-Induced Cytotoxicity Toward RAW 264.7 Cells by Reversing Cell Cycle Arrest and Apoptosis

• Main Authors: Wan-Rong Bao (Author), Zhi-Peng Li (Author), Quan-Wei Zhang (Author), Li-Feng Li (Author), Hong-Bing Liu (Author), Dik-Lung Ma (Author), Chung-Hang Leung (Author), Ai-Ping Lu (Author), Zhao-Xiang Bian (Author), Quan-Bin Han (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: The purpose of this study was to determine if an Astragalus polysaccharide (RAP) can protect immune cells from the toxic side effects of paclitaxel (Taxol), a powerful anti-tumor drug whose equally powerful side effects limit its clinical use.Methods: We hypothesized that RAP can reduce the...