Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer's disease

• Main Authors: Kwangsik Nho (Author), Sungeun Kim (Author), Emrin Horgusluoglu (Author), Shannon L. Risacher (Author), Li Shen (Author), Dokyoon Kim (Author), Seunggeun Lee (Author), Tatiana Foroud (Author), Leslie M. Shaw (Author), John Q. Trojanowski (Author), Paul S. Aisen (Author), Ronald C. Petersen (Author), Clifford R. Jack (Author), Michael W. Weiner (Author), Robert C. Green (Author), Arthur W. Toga (Author), Andrew J. Saykin (Author), for the Alzheimer's Disease Neuroimaging Initiative (ADNI) (Author)
• Format: Book
• Published: BMC, 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The APOE ε4 allele is the most significant common genetic risk factor for late-onset Alzheimer's disease (LOAD). The region surrounding APOE on chromosome 19 has also shown consistent association with LOAD. However, no common variants in the region remain significant after a...