Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure

• প্রধান লেখক: Patricia Rueda (লেখক), Jon Merlin (লেখক), Stefano Chimenti (লেখক), Michel Feletou (লেখক), Jerome Paysant (লেখক), Paul J. White (লেখক), Arthur Christopoulos (লেখক), Patrick M. Sexton (লেখক), Roger J. Summers (লেখক), William N. Charman (লেখক), Lauren T. May (লেখক), Christopher J. Langmead (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Adenosine A1 receptors (A1R) are a potential target for cardiac injury treatment due to their cardioprotective/antihypertrophic actions, but drug development has been hampered by on-target side effects such as bradycardia and altered renal hemodynamics. Biased agonism has emerged as an attractive me...