Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure

• Main Authors: Patricia Rueda (Author), Jon Merlin (Author), Stefano Chimenti (Author), Michel Feletou (Author), Jerome Paysant (Author), Paul J. White (Author), Arthur Christopoulos (Author), Patrick M. Sexton (Author), Roger J. Summers (Author), William N. Charman (Author), Lauren T. May (Author), Christopher J. Langmead (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adenosine A1 receptors (A1R) are a potential target for cardiac injury treatment due to their cardioprotective/antihypertrophic actions, but drug development has been hampered by on-target side effects such as bradycardia and altered renal hemodynamics. Biased agonism has emerged as an attractive me...