Measurable Residual Disease Assessed by Flow-Cytometry Is a Stable Prognostic Factor for Pediatric T-Cell Acute Lymphoblastic Leukemia in Consecutive SEHOP Protocols Whereas the Impact of Oncogenetics Depends on Treatment

• Main Authors: Nerea Vega-García (Author), Sara Perez-Jaume (Author), Elena Esperanza-Cebollada (Author), Clara Vicente-Garcés (Author), Montserrat Torrebadell (Author), Antonio Jiménez-Velasco (Author), Margarita Ortega (Author), Marta Llop (Author), Lorea Abad (Author), José Manuel Vagace (Author), Alfredo Minguela (Author), Marta Pratcorona (Author), Joaquín Sánchez-Garcia (Author), Clara B. García-Calderón (Author), María Teresa Gómez-Casares (Author), Estela Martín-Clavero (Author), Adela Escudero (Author), Marta Riñón Martinez-Gallo (Author), Luz Muñoz (Author), María Rosario Velasco (Author), Marina García-Morin (Author), Albert Català (Author), Antonia Pascual (Author), Pablo Velasco (Author), José Mª. Fernández (Author), Alvaro Lassaletta (Author), José Luis Fuster (Author), Isabel Badell (Author), Águeda Molinos-Quintana (Author), Antonio Molinés (Author), Pilar Guerra-García (Author), Antonio Pérez-Martínez (Author), Miriam García-Abós (Author), Reyes Robles Ortiz (Author), Sandra Pisa (Author), Rosa Adán (Author), Cristina Díaz de Heredia (Author), José Luis Dapena (Author), Susana Rives (Author), Manuel Ramírez-Orellana (Author), Mireia Camós (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Robust and applicable risk-stratifying genetic factors at diagnosis in pediatric T-cell acute lymphoblastic leukemia (T-ALL) are still lacking, and most protocols rely on measurable residual disease (MRD) assessment. In our study, we aimed to analyze the impact of NOTCH1, FBXW7, PTEN, and RAS mutati...