Partial leptin deficiency confers resistance to diet-induced obesity in mice

• Main Authors: Shangang Zhao (Author), Na Li (Author), Yi Zhu (Author), Leon Straub (Author), Zhuzhen Zhang (Author), May-Yun Wang (Author), Qingzhang Zhu (Author), Christine M. Kusminski (Author), Joel K. Elmquist (Author), Philipp E. Scherer (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Hyperleptinemia per se is sufficient to promote leptin resistance in the obese state. Leptin sensitivity can be restored by reducing circulating leptin levels within a physiologically healthy range and is a viable antiobesity and antidiabetic strategy. However, a previous study suggests t...