Stress and Vascular Responses: Atheroprotective Effect of Laminar Fluid Shear Stress in Endothelial Cells: Possible Role of Mitogen-Activated Protein Kinases

• المؤلفون الرئيسيون: Masanori Yoshizumi (مؤلف), Jun-ichi Abe (مؤلف), Koichiro Tsuchiya (مؤلف), Bradford C. Berk (مؤلف), Toshiaki Tamaki (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2003-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Atherosclerosis preferentially occurs in areas of turbulent blood flow and low fluid shear stress, whereas laminar blood flow and high shear stress are atheroprotective. Inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), stimulate expression of endothelial cell (EC) genes that may prom...