The Novel Src Kinase Inhibitor M475271 Inhibits VEGF-Induced Vascular Endothelial-Cadherin and β-Catenin Phosphorylation but Increases Their Association

• Main Authors: Nermin Ali (Author), Masanori Yoshizumi (Author), Seiji Yano (Author), Saburo Sone (Author), Hideki Ohnishi (Author), Keisuke Ishizawa (Author), Yasuhisa Kanematsu (Author), Koichiro Tsuchiya (Author), Toshiaki Tamaki (Author)
• Format: Book
• Published: Elsevier, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

M475271, 4-quinazolinamine, N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl) methoxy]-(9Cl), is a new anilinoquinazoline derivative that displays selective inhibition of Src kinase activity and tumor growth in vivo. Vascular endothelial growth factor (VEGF)-induced angiogenesis pla...