External Evaluation of Population Pharmacokinetic Models and Bayes-Based Dosing of Infliximab

• Main Authors: Celine Konecki (Author), Catherine Feliu (Author), Yoann Cazaubon (Author), Delphine Giusti (Author), Marcelle Tonye-Libyh (Author), Hedia Brixi (Author), Guillaume Cadiot (Author), Amélie Biron (Author), Zoubir Djerada (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite the well-demonstrated efficacy of infliximab in inflammatory diseases, treatment failure remains frequent. Dose adjustment using Bayesian methods has shown in silico its interest in achieving target plasma concentrations. However, most of the published models have not been fully validated in...