Essential role of ALKBH5-mediated RNA demethylation modification in bile acid-induced gastric intestinal metaplasia

• Main Authors: Ben Yue (Author), Ran Cui (Author), Ruizhe Zheng (Author), Weilin Jin (Author), Chenlong Song (Author), Tianshang Bao (Author), Ming Wang (Author), Fengrong Yu (Author), Enhao Zhao (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bile acid reflux and subsequent caudal-related homeobox 2 (CDX2) activation contribute to gastric intestinal metaplasia (IM), a precursor of gastric cancer; however, the mechanism underlying this phenomenon is unclear. Here, we demonstrate that alkylation repair homolog protein 5 (ALKBH5), a major R...