Aptamer-based nanotrains and nanoflowers as quinine delivery systems

• Main Authors: Mengyuan Cao (Author), Anthony Vial (Author), Laetitia Minder (Author), Aurore Guédin (Author), Sébastien Fribourg (Author), Laurent Azéma (Author), Cécile Feuillie (Author), Michael Molinari (Author), Carmelo Di Primo (Author), Philippe Barthélémy (Author), Leblond Chain Jeanne (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we designed aptamer-based self-assemblies for the delivery of quinine. Two different architectures were designed by hybridizing quinine binding aptamers and aptamers targeting Plasmodium falciparum lactate dehydrogenase (PfLDH): nanotrains and nanoflowers. Nanotrains consisted in cont...