Prolyl-hydroxylase inhibitor-induced regeneration of alveolar bone and soft tissue in a mouse model of periodontitis through metabolic reprogramming

• Main Authors: Elan Zebrowitz (Author), Azamat Aslanukov (Author), Tetsuhiro Kajikawa (Author), Kamila Bedelbaeva (Author), Sam Bollinger (Author), Yong Zhang (Author), David Sarfatti (Author), Jing Cheng (Author), Phillip B. Messersmith (Author), George Hajishengallis (Author), Ellen Heber-Katz (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bone injuries and fractures reliably heal through a process of regeneration with restoration to original structure and function when the gap between adjacent sides of a fracture site is small. However, when there is significant volumetric loss of bone, bone regeneration usually does not occur. In th...