A novel mouse model of tuberous sclerosis complex (TSC): eye-specific Tsc1-ablation disrupts visual-pathway development

• Main Authors: Iwan Jones (Author), Anna-Carin Hägglund (Author), Gunilla Törnqvist (Author), Christoffer Nord (Author), Ulf Ahlgren (Author), Leif Carlsson (Author)
• Formato: Libro
• Publicado: The Company of Biologists, 2015-12-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Tuberous sclerosis complex (TSC) is an autosomal dominant syndrome that is best characterised by neurodevelopmental deficits and the presence of benign tumours (called hamartomas) in affected organs. This multi-organ disorder results from inactivating point mutations in either the TSC1 or the TSC2 g...