Antifibrotic effect of the P2X7 receptor antagonist A740003 against acute myocardial infarction-induced fibrotic remodelling

• Main Authors: Noura Almusallam (Author), Asma Alonazi (Author), Anfal Bin Dayel (Author), Abdullah Almubarak (Author), Rizwan Ali (Author), Wajd Althakfi (Author), Rehab Ali (Author), Nouf Alrasheed (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Post-acute myocardial infarction (AMI) fibrosis is a pathophysiologic process characterised by activation of the profibrotic mediator, transforming growth factor-β (TGF-β). AMI is associated with a substantial increase in the levels of extracellular adenosine triphosphate (eATP), which acts on the p...