EM23, a natural sesquiterpene lactone from Elephantopus mollis H.B.K., induces apoptosis in human myeloid leukemia cells through thioredoxin- and reactive oxygen species-mediated signaling pathways

• Main Authors: Hongyu eLi (Author), Manmei eLi (Author), Guocai eWang (Author), Fangyuan eShao (Author), Wenbo eChen (Author), Chao eXia (Author), Sheng eWang (Author), Yaolan eLi (Author), Guangxiong eZhou (Author), Zhong eLiu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Elephantopus mollis H.B.K. (EM) is a traditional herbal medicine with multiple pharmacological activities. However, the efficacy of EM in treating human leukemia is currently unknown. In the current study, we report that EM23, a natural sesquiterpene lactone isolated from EM, inhibits the proliferat...