Leptin and insulin engage specific PI3K subunits in hypothalamic SF1 neurons

• Egile Nagusiak: Jong-Woo Sohn (Egilea), Youjin Oh (Egilea), Ki Woo Kim (Egilea), Syann Lee (Egilea), Kevin W. Williams (Egilea), Joel K. Elmquist (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2016-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Objective: The ventromedial hypothalamic nucleus (VMH) regulates energy balance and glucose homeostasis. Leptin and insulin exert metabolic effects via their cognate receptors expressed by the steroidogenic factor 1 (SF1) neurons within the VMH. However, detailed cellular mechanisms involved in the...