Dynamics of T-cell Responses Following COVID-19 mRNA Vaccination and Breakthrough Infection in Older Adults

• Main Authors: Sneha Datwani (Author), Rebecca Kalikawe (Author), Francis Mwimanzi (Author), Sarah Speckmaier (Author), Richard Liang (Author), Yurou Sang (Author), Rachel Waterworth (Author), Fatima Yaseen (Author), Hope Lapointe (Author), Evan Barad (Author), Mari DeMarco (Author), Daniel Holmes (Author), Janet Simons (Author), Julio Montaner (Author), Marc Romney (Author), Zabrina Brumme (Author), Mark Brockman (Author)
• Format: Book
• Published: Case Western Reserve University, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: While older adults generally mount weaker antibody responses to a primary COVID-19 vaccine series, T-cell responses remain less well characterized in this population. We compared SARS-CoV-2 spike-specific T-cell responses after 2- and 3-dose COVID-19 mRNA vaccination and subsequent bre...