Development of Meloxicam-Human Serum Albumin Nanoparticles for Nose-to-Brain Delivery via Application of a Quality by Design Approach

• Main Authors: Gábor Katona (Author), György Tibor Balogh (Author), Gergő Dargó (Author), Róbert Gáspár (Author), Árpád Márki (Author), Eszter Ducza (Author), Anita Sztojkov-Ivanov (Author), Ferenc Tömösi (Author), Gábor Kecskeméti (Author), Tamás Janáky (Author), Tamás Kiss (Author), Rita Ambrus (Author), Edina Pallagi (Author), Piroska Szabó-Révész (Author), Ildikó Csóka (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2020-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

The aim of this study was to optimize the formulation of meloxicam (MEL)-containing human serum albumin (HSA) nanoparticles for nose-to-brain via a quality by design (QbD) approach. Liquid and dried formulations of nanoparticles containing Tween 80 and without the surfactant were investigated. Vario...